Background: CONGENITAL HEART DISEASE (CHD) is the most common CONGENITAL disorder in neonates. Many factors are associated with the occurrence of the CHD, including genetic factors, teratogenic exposure and several other unrecognized factors. Objectives: This study aims to investigate the role of several potential factors associated with the occurrence of CHD. Methods: This study was conducted as a cross-sectional case-control study, in Imam Khomeini Hospital Complex, Tehran, Iran. A total of 1338 known cases of CHD, diagnosed by echocardiography or angiography and 1201 healthy children as the controls were included in this study. Factors that could have an association with CHD were investigated by a questionnaire from all participants. Results: Maternal age above 30 years (P-value < 0. 001), positive parents’,consanguinity (P-value < 0. 001) and previous maternal history of abortion (P-value < 0. 001) was signifi, cantly higher among patients with CHD,furthermore, positive history of CHD among siblings of the known cases of CHD was higher than healthy ones (P-value < 0. 001). The mean birth weight in case and control group were 3 (+ 0. 648) and 2. 9 (+ 0. 707) kilograms, respectively. The maternal age in 983 (73. 4%) cases and 960 (79. 93%) controls was below the 30 years, the maternal age for other participants was above the 30 years (P-value < 0. 001). Conclusions: All factors except the history of stillbirth, maternal underlying DISEASE and drug use during pregnancy in the case group were signifi, cantly diff, erent with the control group. It seems that the causes of CHD in Iran are most commonly related to the hereditary genetic factors, and the increased maternal age, drug use, and underlying DISEASEs in the mother are a matter of less importance.

Introduction: CONGENITAL HEART DISEASE (CHD) can have oral manifestations that even the patient may not be aware of. These manifestations could be linked to the DISEASE itself or the treatment associated with it. Also, since a history of CHD may alter the treatment plan of some of the oral DISEASEs or some oral DISEASEs may affect the course of CHD, the current research was designed to better understand such interrelationships. Materials & Methods: In this cross-sectional descriptive study, 42 CHD patients that were admitted to the department of Internal Medicine of Imam Reza Hospital, Mashhad, Iran, were randomly investigated for a period of one year through a questionnaire and routine examinations and the final results are descriptively presented. Results: In 17 cases (40.5%), cyanotic mucosa was reported and in 6 cases (14.4%) pale tissues were noted. In 2 cases cleft palate (4.7%) and cleft lips (4.7%) were recorded. Conclusion: Oral manifestations recorded for patients with CHD were Cyanosis, pale tissues and cleft and palatte and lip. Although clefting and palate lip can not be directly linked to CHD, their presence in conjunction with CHD should be considered.

Objective: Osteogenesis imperfect (OI) is an inherited disorder of type1 collagen synthesis with varied complication. OI type II is a perinatally lethal variety, characterized by short limbs, broad long bones, radiologic evidence of severe osseous fragility and defective ossification. These patient usually are stillborn or die in early infancy of respiratory failure.  It has a wide range of phenotypic expressions, but cardiovascular anomalies tend to be rare association. When they do occur, they usually consist of aortic or mitral valve DISEASE. Case Presentation: Here we come across a rare case of OI type II in a neonate with acyanotic CONGENITAL HEART DISEASE. Echocardiography revealed moderate size ostium secundum atrial septal defect without pulmonary hypertension. The patient expired after 6 hour of life.Conclusion: Any case of OI should be screened for CONGENITAL cardiovascular defect and another abnormality.

Introduction: Patients with cyanotic HEART DISEASE may have an acceptable quality of life. However, they are invariably prone to several complications. The aim of this study is search about hematologic abnormalities in cyanotic CONGENITAL HEART DISEASE patients.Materials and Methods: In this cross-sectional study, every cyanotic CONGENITAL HEART DISEASE patients who was referred to the adult CONGENITAL HEART DISEASE clinic was selected and asked of any possible hyperviscosity symptoms, gingival bleeding, epistaxis, hemoptysis, hypermenorrhagia, and gouty arthritis irrespective of their age, gender and primary diagnosis in a six-month period.In this regard, 02 saturation was obtained via pulse oximetry, an abdominal ultrasound was done in order to discover any gallstones and laboratory tests including CBC, coagulation parameters (bleeding time (BT), clotting time (CT), prothrombin time (PT), international ratio (INR), Ferritin, blood urea nitrogen (BUN) and creatinine (Cr) were provided as well.Results: A total of 69 patients were enrolled in the present study. The mean age of the patients was 22.44±5.72. Twenty two (34.4%) of them were female and 45 (65.6%) were male. In our research, 23% of the patients had serum levels of uric acid more than or equal to 8 mg/dl.59%of patients presented with depleted iron storage. Mean hemoglobin (Hg), level was (16.9±2.5 mg/dl), mean hematocrit (HCT) level was (55.47±9 mg/dl), mean Ferritin level was (32.5±0.4).Our collected data also revealed that plasma creatinine concentration was normal (0.9±0.2 mg/dl). Furthermore, thrombocytopenia of less than 160000 was found in 30% of the patients. Hyperviscosity symptoms also found in 1.3% of patients.Conclusion: Our patients had less hyperuricemia, there is no correlation between hyperviscosity symptoms and haematocrit level and an inverse correlation between the Ferritin level and hyperviscosity symptoms were seen.